Monolithic LC columns.

Recently, monolithic columns consisting of one piece of an organic polymer or silica with flow-through pores have been reported in the literature. These materials provide better stability and, more important, higher performance than conventional columns packed with particles. Although they can be prepared by various methods, monolithic columns prepared by the direct polymerization of monomers can be used in various analytical separations by HPLC and capillary electrochromatography (CEC). This article will show the structural and chromatographic features of these monolithic columns.